

There are many different strains of E. coli, some harmful and some harmless. Each strain is different in it's characteristics. There are many different strains of E. coli because E. coli is strongly drug resistant and is constantly evolving to avoid the antibiotics that are used to try and fight it (such as streptomycin or gentamicin.) The strong drug resistance of E. coli can make it hard to fight, but when diagnosed early on, there are many existing drugs that can identify, locate, and exterminate the harmful strains of E. coli in you. E. coli can cause a variety of diseases, and also a wide range of severity of these diseases depending on age, immune system effectiveness, how early it is diagnosed, and how well and properly it is treated.
Sources:
http://en.wikipedia.org/wiki/Escherichia_coli
http://www.lbl.gov/Publications/Currents/Archive/Mar-05-2004.html
http://science.howstuffworks.com/environmental/life/cellular-microscopic/cell1.htm