Showing posts with label Genes. Show all posts
Showing posts with label Genes. Show all posts

Thursday, April 21, 2011

Reflecting on Genetics

After filling out the genetic trait chart in the Human Heredity lab for myself and my classmates, I used the data to predict whether each trait was dominant or recessive. I found that not all of my predictions were correct, in fact only two of my five predictions held true. This surprised me at first, but can be explained by the fact that our class of 14 kids is a very small sample pool compared to the census of millions of people that scientists must have taken to determine genes dominant or recessive. 6 out of 14 kids in our class could taste the PIC strips, so I predicted that it was a recessive trait. However it turns out that PIC tasting is a dominant trait, which didn't surprise me that much because 6 out of 14 is nearly half the class. 11 out of 14 kids in our class could roll their tongues, so it was easy to predict correctly that tongue-rolling is a dominant trait. Only 4 out of 14 kids in our class had attached ear lobes, so it was also easy to guess correctly that an attached ear lobe is a recessive trait. 7 out of 14 kids in our class had hitch hiker's thumbs, exactly half, so I just took a wild guess that it was a dominant trait, when in fact it turned out to be a recessive gene. Lastly and most surprisingly 6 out of 14 kids in our class had a widow's peak, so I predicted that it was a recessive trait, only to learn that it is a dominant trait. This surprised me because I would expect at least half of our class to have a widow's peak if it is a dominant trait, but as Mrs. McCurdy explained, a widow's peak isn't exactly an admirable trait to have, and humans may have evolved through genetic variation so that fewer and fewer people have widow's peaks, even if it is indeed a dominant trait.

I am a tongue roller, have an attached ear lobe, have a hitch hiker's thumb, and have a widow's peak, and unfortunately for the sake of a more interesting pool of data, both of my parents share all of the same traits as me. I was able to deduct a few genotypes of the recessive traits I have from this lab though. Having attached ear lobes is a recessive trait that both my parents and I posses, therefore I know that we all must have an homozygous recessive aa genotype. Having hitch hiker's thumbs is also a recessive trait that both my parents and I posses, so I can conclude that we all must have a homozygous recessive hh genotype. As far as the tongue rolling and widow's peaks go, both my parents and I all have the dominant trait, so we all could be either homozygous dominant TT or heterozygous Tt, but there is no way of telling which without collecting data from previous generations.


Lastly, there were four Mendelian traits I found that surprised me while I was researching whether the traits in this lab were dominant or recessive. The first of the traits which surprised me was dimples. Dimples is a dominate trait, while I only know two people who have dimples, which is why the fact that it is a dominate trait surprised me so much. The second trait which surprised me was tall and short stature. I found that short stature was actually a dominate trait, which surprised me because most of the people I know desire to be tall, but we are naturally supposed to be short. I would have thought that humans would have evolved genetically overtime so that it would be a dominate trait to be tall, but tall stature is listed as a recessive trait. The third trait which shocked me was dwarfism. Dwarfism is a dominate trait, when in fact I am not aware of anyone in my life that has dwarfism. I assume that dwarfism is one of the traits that humans have evolved over time to avoid, because I know so few people who have dwarfism, or who desire to have dwarfism. The last and most shocking Mendelian trait that I found in my research was six fingers as opposed to the normal five fingers. Having six fingers per hand is the dominant trait, when in fact I don't know a single person who has six fingers, which is why it surprised me so much. I would assume that this is a trait that humans have evolved to avoid as well, which is a pattern that I'm starting to see with undesirable traits, and one that I'm sure i'll see more of as we continue with our genetics unit.  

Source for the Mendelian Traits:
http://education.sdsc.edu/download/enrich/mendelian_traits.pdf

Wednesday, February 23, 2011

The Link Between Laron's and Cancer

           While most of the things you hear related to cancer are in a negative light, such as alcohol and smoking, Laron's disease has a positive connection to cancer. People who have Laron's disease are immune to cancer and diabetes. Laron's disease is cause by a mutation in the growth hormone receptor (GHR) which leads to the production of insulin like growth factor 1 (IGF1). People who have mutations in both GHR genes tend to have Laron's disease and in result have little production of IGF1.
Now that scientists know that small amounts of IGF1 can lead to immunity of cancer and diabetes, the question may be posed, why don't we all have IGF1 taken out of us? Well the fact is that successful tests have been conducted on animals, but there are too many risks involved for testing to be conducted on humans. After reading this article: http://www.msnbc.msn.com/id/41632071/ns/health-aging/, I had conflicted feelings about the new discovery about the link between Laron's and cancer. My initial thoughts while reader were, if we know how to be immune to two diseases that are killing millions of people each year then why don't we just do it already. But then I realized that surely immunity of cancer and diabetes couldn't come that easily and without other risks. 
           One particular line stuck out to me in this article, "Everything is inter-related in our bodies. In general, I panic when people jump to conclusions too fast"-Felipe Sierra. I agree strongly with this statement, and I feel that it's a shame that we now have the resources to become immune to cancer, and yet we have to wait yet again for more research to be conducted before we can actually implement the findings in humans. It's almost like scientists are teasing us by releasing this information to the public, but I also think that this study gives us hope for the future. If we now have a link between Laron's and immunity to cancer and diabetes, further research and tests can be done until scientists are confident enough that we can use this information to make humans immune to cancer without overwhelming risks. I left reading this article with a positive view on the future for cancer, and believe that with our ever-progressing technology, scientists will be able to uncover more links between gene mutations and cancer, and eventually be able to cure this horrible disease.


Sources: 
http://www.dailymail.co.uk/news/worldnews/article-1045987/Immune-cancer-The-astonishing-dwarf-community-Ecuador-hold-key-cure.html


http://www.msnbc.msn.com/id/41632071/ns/health-aging/